UNIVERSITY OF MINNESOTA | DEPARTMENT OF NEUROSURGERY
UNIVERSITY OF MINNESOTA | DEPARTMENT OF NEUROSURGERY
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Tumors can evolve without changing their genome.
Tumors can evolve without changing their genome.
We study how.
We study how.
The Venteicher Lab investigates the non-canonical mechanisms driving brain tumor formation, evolution, and immune evasion — using single-cell genomics, epigenomics, and biochemistry on patient-derived specimens to find new therapies where few exist.
01
Brain tumors
Tens of thousands are diagnosed with brain and skull base tumors in the U.S. each year. Many progress despite surgery, chemotherapy, and radiation – creating urgency for new treatments.
02
Molecular prognostics
Patients with CNS tumors show great variability in outcome and survival. We use epigenomics, biochemistry, and computational approaches to find molecular signals that predict it.
03
Epigenetic dynamics
Tumorigenesis can occur without genetic mutations or chromosomal changes. We study the non-genetic mechanisms behind tumor evolution and immune evasion at single-cell resolution.
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